Hemosilate 5 vials x 20 ml

Target species
Cattle, sheep, goat, pig, horse, dog and cat.

Indications for use, specifying the target species
Prevention and treatment of surgical, post traumatic, obstetric and gynecological hemorrhages.

Amounts to be administered and administration route
For all the species: Intravenous or intramuscular route.
– 5 to 12.5 mg of etamsilate/kg bw, equivalent to 0.04 to 0.1 ml/ kg/day of the veterinary medicinal product, according to the severity of the process.
For prevention of surgical bleeding it should be administered at least 30 minutes before surgery.
For treatment of an ongoing process, it can be administered up to every 6 hours until bleeding has stopped completely.

Pharmacodynamic properties
Ethamsylate is a hemostatic and angioprotective drug that stimulates platelet adhesiveness shortening bleeding time and normalizing rapidly and lastly the altered vascular fragility and permeability.
Its mechanism of action is attributed to the inhibition of prostacyclin (PGI2) synthesis that causes the platelet disaggregation, vasodilation and increase of capillary permeability and to the activation of P-selectine, which facilitates the interaction between platelets, leucocytes and
endothelium. It acts on primary hemostasis without affecting prothrombin time, fibrinolysis or platelet count.
In animal models of capillary bleeding, the administration of etamsylate shortens bleeding time and the severity of the hemorrhage up to 50% reaching its maximum effect between 30 minutes and 4 hours after its administration.

More information can be found on the following link: Hemosilate